The Key to this card is the fact it is an "Action" and not a "Hero Action". Allowing you to heal other players while getting the superior card draw from AE mode and set-up your own board is this card's big strength
As of this listing, there are two heroes who should likely be putting this into a Multiplayer Protection Build: She-Hulk and Wasp.
She-Hulk is already looking for Mental symbols for Superhuman Law Division. Her +2 cards in AE mode gives her a lot of incentive to create builds to take advantage of that, and between her AE ability and Superhuman Law Division, it's easy to maintain a 3 threat reduction off the main scheme every turn. This card allows her to act as a pocket healer but still swinging up to do burst damage like She-Hulk likes to do in Hero mode.
Wasp loves Mental symbols, and operates in a tool kit style. She is able to reshuffle Second Wind back into the deck when ever the board needs it. Her ability to also shuffle back in copies of Perseverance in conjunction, gives her the opportunity to heal herself or others and flip up with a Tough token. With other great cards like Pin-Point Strike and Giant Help grabbable by GIRL as well, you're able to reload on your most needed cards to take care of any situation.