Black Widow - Run Away and Fight!

The main idea of this deck is to take advantage of going to AE every turn. Play Preparation cards with your Gauntlets and get and extra card draw.

Try to end your turn in AE with Ready for a Fight on the board. When the villain attacks, use Ready for a Fight to flip up, and activate Widowmaker. Maybe you can use a Practiced Plan to put Ready for a Fight back into your hand and active Widowmaker again. Exhaust to defend with Synth-Suit in play, use a Defensive Stance or Attacrobatics to take no damage (activating Widowmaker a third time) and ready via Synth-Suit. Feel free to use Nova against the villain or an minion, if you have Quincarrier out you have the right resource guaranteed.

If you took no damage you get Unflappable and Hard to Ignore triggers. If you took out a minion with all of those Widowmakers/Nova you get a Change of Fortune.

After all of your Hero side stuff go back to AE and use your Safe House to bring one of those Perpetrations back to hand where you can play it, triggering Mission Prep. Note that your Gauntlet's are wild so they can pay for Ready for a Fight.

You cycle cards like crazy, especially if you can get Change of Fortune going.

What is the Repurpose doing? well you can always Repurpose a Grappling Hook or Widow's Bite and get them right back via Safe House.

What Doesn't Kill Me might be a weak card if you don't take any damage so that might be something to remove (get one more Repurpose) but it also works as a nice insurance heal plus give a physical recourse.