Ghost-Spider is naturally aggressive

The conventional wisdom is that Ghost Spider is best in Protection, and she is absolutely great at it. But I am here to argue that Aggression is her best aspect.

The number one reason is this: Ghost Spider has 10 events in her deck that trigger her Dizzying Reflexes. All 10 of them work in the Villain Phase, only 6 work in the Hero Phase. In Protection, all response and interrupt events (that are practical for Ghost Spider.) only work in the Villain phase. So in Protection, you are limited to 6 hero phase readies in a deck cycle. With good card luck and use of George Stacy, that can work. But, in my experience, card luck is fleeting (And Web-Bracelets always find their way to the bottom of the deck.) so I would rather hedge against card luck. In this deck you have 12 cards that work in the villain phase and 11 in the hero phase per deck cycle, making it more likely that you can utilize Dizzying Reflexes in both phases.

The number two reason is this: Protection cards boost defence, Aggression cards boost attack. Attack is how you win most scenarios. And since she is defending most attacks with 3 defence, defence is already mostly covered. I am not that bothered about taking chip damage. And chump blocking can be used when villains get a second activation.

The idea here is that "You'll Pay for That!", Chase Them Down, Critical Hit, Moment of Triumph, and The Best Defense… are the targets for George Stacy because they are situational.

Web-Bracelet, (Or Superpower Training), Web of Life and Destiny and Specialized Training are mulligan priorities to get card draw. Combat Training should be put in play because damage from multiple activations is the purpose of the deck. While "Now I'm Mad" and Warrior of the Great Web fit that, they are circumstantial, so if it gets skipped for the second pass that is fine. Symbiote Suit can be added with the same logic.

Skilled Strike is the only Aggression event I put 3 copies of because it is the easiest to use. Ever turn you should be attacking, so it should get lots of use. The 0 cost is nice if you don't get card draw online early.

Once set up, Ghost Spider deals consistent and reliable high damage turns that will make short work of any scenario.

Once set up, this deck produces consistent and repeatable damage. Two hits of 4 damage is a minimum baseline, but can easily get over 20 damage with Spider-Man in play. Making short work of enemies in solo and more than pulling your weight in multiplayer.