Adam Warlock Deletes the Marvel Universe

For playing against Mysterio with the Space Pirates modular set. Let Mysterio put his Illusions into your deck, put other cards there yourself with Humongous Hallucination, then take hits from Pirate Lackeys (and maybe the Commander) to remove them from the game.

Gambit, Spider-Man Noir, Show of Empathy, and The Raft help you remove cards as well, especially Minions. "Come Get Me, Bub!" and Looking for Trouble taunt said Minions to within your grasp. Gambit, Tempus (playable via Summoning Spell and Call for Backup), Front Organization, and Target Acquired help protect you from nasty surprises. The Triskelion lets you keep Gambit, Spider-Man Noir, and the Redeemed Minion in play with enough room for another Ally.

Bonus points if you can turn the Encounter deck into only Cosmic Entity cards. Spider-Ham (playable as is Tempus above but also if Spider-Man Noir is already in play) can help you keep Eternity, In-Betweener, Living Tribunal, and The Gardener around until that time while simultaneously avoiding consequential damage.

All the rest is your basic Mystic good stuff package. Good luck and have fun!