Extremely good card for Protection Thor (who becomes Aerial thanks to Mjolnir), or Spectrum in Gamma form, granting 2 threat removal plus at least 3 damage for 3 ER, an astonishingly good ratio (compare with Hit and Run which only grants 2 damage and 2 threat removal for 4 ER).
Obviously good for Angel as well, who draws a card when playing it, and for Nova, who relies on basic powers to generate resources from his Supernova Helmet, less so for Ironheart who, even if Aerial from the start, has lower basic stats and no particular need of readying herself often.
Many other characters can benefit from this card (Captain Marvel, Iron Man, Wasp, Star-Lord, Vision, War Machine, Valkyrie, Phoenix, Storm, Rogue, Magneto), although none of them is Aerial right from the start like the ones I mentioned above and thus have to rely on cards that make them become so. Personally, I wouldn't include Aerial cards in these characters' decks if I have to rely to a lucky draw, except maybe Iron Man and Magneto who have the means to tutor the cards that make them Aerial.
However, special mentions go to Doctor Strange, who gains Aerial from his Cloak of Levitation and loves to ready himself so he can cast more invocations, and Iceman who gets Aerial with his Ice Slide and loves to use his basic powers to attach more Frostbite to his enemies. If you play these characters with the Protection aspect, Ever Vigilant may be worth including.